Assay Detail
Binding
CHEMBL5100438
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DTG from human sigma2 receptor expressed in human HEK293T cell membrane incubated for 90 mins by radioligand binding assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Studies of 1<i>H</i>-Imidazo[4,5-<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.78 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5190388 | — | — | 1 | 6.24 |
| CHEMBL5170790 | — | — | 1 | 6.05 |
| CHEMBL5183188 | — | — | 1 | 6.04 |
| CHEMBL5173661 | — | — | 1 | 5.87 |
| CHEMBL5177682 | — | — | 1 | 5.87 |
| CHEMBL5170354 | — | — | 1 | 5.55 |
| CHEMBL5195535 | — | — | 1 | 5.52 |
| CHEMBL5174205 | — | — | 1 | 5.46 |
| CHEMBL5186785 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5190388 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL5170790 | — | Ki | = | 891.0 | nM | 6.05 |
| CHEMBL5183188 | — | Ki | = | 907.0 | nM | 6.04 |
| CHEMBL5173661 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL5177682 | — | Ki | = | 1340.0 | nM | 5.87 |
| CHEMBL5170354 | — | Ki | = | 2840.0 | nM | 5.55 |
| CHEMBL5195535 | — | Ki | = | 3010.0 | nM | 5.52 |
| CHEMBL5174205 | — | Ki | = | 3430.0 | nM | 5.46 |
| CHEMBL5186785 | — | Ki | = | 3620.0 | nM | 5.44 |