Assay Detail
Binding
CHEMBL5104248
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Displacement of [3H]-flunitrazepam from TSPO receptor in Wistar rat brain without cerebellum incubated for 90 mins by liquid scintillation counter analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An update into the medicinal chemistry of translocator protein (TSPO) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.50 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5193551 | — | — | 1 | 9.30 |
| CHEMBL481537 | PK-11195 | — | 1 | 8.94 |
| CHEMBL54349 | ALPIDEM | 4.0 | 1 | 8.10 |
| CHEMBL5191240 | — | — | 1 | 7.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5193551 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL481537 | PK-11195 | Ki | = | 1.14 | nM | 8.94 |
| CHEMBL54349 | ALPIDEM | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL5191240 | — | Ki | = | 22.2 | nM | 7.65 |