Assay Detail
Functional
CHEMBL5105320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis of novel triptolide-glucose conjugates targeting glucose Transporter-1 and their selective antitumor effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.11 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | 3.0 | 1 | 8.70 |
| CHEMBL5209298 | — | — | 1 | 5.94 |
| CHEMBL5181712 | — | — | 1 | 5.73 |
| CHEMBL5180561 | — | — | 1 | 5.69 |
| CHEMBL5198402 | — | — | 1 | 5.66 |
| CHEMBL5201865 | — | — | 1 | 5.60 |
| CHEMBL5194306 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5209298 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5181712 | — | IC50 | = | 1859.0 | nM | 5.73 |
| CHEMBL5180561 | — | IC50 | = | 2038.0 | nM | 5.69 |
| CHEMBL5198402 | — | IC50 | = | 2213.0 | nM | 5.66 |
| CHEMBL5201865 | — | IC50 | = | 2508.0 | nM | 5.60 |
| CHEMBL5194306 | — | IC50 | = | 3421.0 | nM | 5.47 |