Assay Detail
Binding
CHEMBL5105892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DYRK1A (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (CHEMBL2292) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A critical update on the strategies towards small molecule inhibitors targeting Serine/arginine-rich (SR) proteins and Serine/arginine-rich proteins related kinases in alternative splicing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.12 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297639 | LORECIVIVINT | 3.0 | 1 | 7.57 |
| CHEMBL1236620 | — | — | 1 | 7.26 |
| CHEMBL1946917 | — | — | 1 | 7.17 |
| CHEMBL5191815 | — | — | 1 | 7.13 |
| CHEMBL269538 | HARMINE | 1.0 | 1 | 7.10 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297639 | LORECIVIVINT | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL1236620 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1946917 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5191815 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL269538 | HARMINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 330.0 | nM | 6.48 |