Compound Detail
CHEMBL5191815
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Basic Information
| ChEMBL ID | CHEMBL5191815 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JAPARGBKJNWVFK-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
267.3
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.13
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | IC50 | 7.13 | 7.13 | 74.0 | 1 |
| Glycogen synthase kinase-3 CHEMBL2095188 | IC50 | 6.42 | 6.42 | 380.0 | 1 |
| Cyclin-dependent kinase 5 CHEMBL4036 | IC50 | 5.57 | 5.57 | 2700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 74.0 | nM | 7.13 | Inhibition of DYRK1A (unknown origin) | 35863237 |
| Glycogen synthase kinase-3 | IC50 | = | 380.0 | nM | 6.42 | Inhibition of GSK3 (unknown origin) | 35863237 |
| Cyclin-dependent kinase 5 | IC50 | = | 2700.0 | nM | 5.57 | Inhibition of CDK5 (unknown origin) | 35863237 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35863237 | 10.1016/j.bmc.2022.116921 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
| 35863237 | 10.1016/j.bmc.2022.116921 | Cyclin-dependent kinase 5 | 1 |
| 35863237 | 10.1016/j.bmc.2022.116921 | Glycogen synthase kinase-3 | 1 |
Data from ChEMBL 36 via Core Engine