Assay Detail
Binding
CHEMBL5106294
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Cathepsin K
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.91 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5200434 | — | — | 1 | 9.30 |
| CHEMBL5178296 | — | — | 1 | 9.30 |
| CHEMBL5187327 | — | — | 1 | 9.22 |
| CHEMBL5203617 | — | — | 1 | 9.15 |
| CHEMBL5177796 | — | — | 1 | 9.15 |
| CHEMBL523352 | — | — | 1 | 8.74 |
| CHEMBL5187747 | — | — | 1 | 8.28 |
| CHEMBL5203247 | — | — | 1 | 8.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5200434 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5178296 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5187327 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5203617 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5177796 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL523352 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5187747 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL5203247 | — | IC50 | = | 6.9 | nM | 8.16 |