Assay Detail
Binding
CHEMBL5107168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His6-tagged recombinant human BRD4 BD1 using (SGRGK(Ac)GGK(Ac)GLGK(Ac)GGAK(Ac)RHGSGSK-biotin) as substrate by TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Linker-Dependent Folding Rationalizes PROTAC Cell Permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.63 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854720 | — | — | 1 | 8.00 |
| CHEMBL4848064 | — | — | 1 | 7.47 |
| CHEMBL5178566 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854720 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4848064 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5178566 | — | IC50 | = | 38.0 | nM | 7.42 |