Assay Detail
Binding
CHEMBL5107240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Menin/fluorescein labeled MLL(4 to 43 residues) (unknown origin) protein protein interaction incubated for 1 hr by fluorescence polarization-based competitive binding assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Menin/Histone-lysine N-methyltransferase MLL (CHEMBL2093861) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Discovery of Novel, Potent, and Selective Small-Molecule Menin-Mixed Lineage Leukemia Interaction Inhibitors through Attempting Introduction of Hydrophilic Groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.76 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5192780 | — | — | 1 | 8.15 |
| CHEMBL5182826 | — | — | 1 | 8.00 |
| CHEMBL5184080 | — | — | 1 | 7.52 |
| CHEMBL5194018 | — | — | 1 | 7.22 |
| CHEMBL5201656 | — | — | 1 | 7.22 |
| CHEMBL5204727 | — | — | 1 | 7.22 |
| CHEMBL5195611 | — | — | 1 | 7.16 |
| CHEMBL5201049 | — | — | 1 | 7.05 |
| CHEMBL5172930 | — | — | 1 | 6.92 |
| CHEMBL5187553 | — | — | 1 | 6.89 |
| CHEMBL5188417 | — | — | 1 | 6.75 |
| CHEMBL5183465 | — | — | 1 | 6.72 |
| CHEMBL5201608 | — | — | 1 | 6.58 |
| CHEMBL5206167 | — | — | 1 | 6.54 |
| CHEMBL5189910 | — | — | 1 | 6.28 |
| CHEMBL5207604 | — | — | 1 | 6.23 |
| CHEMBL3586089 | — | — | 1 | 6.22 |
| CHEMBL5176172 | — | — | 1 | 6.17 |
| CHEMBL5190068 | — | — | 1 | 6.16 |
| CHEMBL5200814 | — | — | 1 | 6.09 |
| CHEMBL5173912 | — | — | 1 | 6.01 |
| CHEMBL5172411 | — | — | 1 | 5.71 |
| CHEMBL5176450 | — | — | 1 | - |
| CHEMBL5180808 | — | — | 1 | - |
| CHEMBL5194989 | — | — | 1 | - |
| CHEMBL5188240 | — | — | 1 | - |
| CHEMBL5202295 | — | — | 1 | - |
| CHEMBL5194316 | — | — | 1 | - |
| CHEMBL5191951 | — | — | 1 | - |
| CHEMBL5202282 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5192780 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5182826 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5184080 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5194018 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5201656 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5204727 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5195611 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5201049 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5172930 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5187553 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5188417 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5183465 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5201608 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5206167 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5189910 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5207604 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3586089 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5176172 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5190068 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5200814 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5173912 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5172411 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL5207278 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5198558 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5208035 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5205955 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5201801 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5200144 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5175946 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5177194 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5202282 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5191951 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5194316 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5202295 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5188240 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5194989 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5180808 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5176450 | — | IC50 | > | 10000.0 | nM | - |