Assay Detail
Functional
CHEMBL5107521
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Antibacterial activity against intracellular multidrug-resistant Salmonella typhimurium ATCC14028 infected in mouse RAW264.7 cells assessed as reduction in intracellular bacterial survival level by RFP staining based high-content image analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Salmonella typhimurium (CHEMBL351) ↗| Type | ORGANISM |
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium |
Publication
Discovery of antipsychotic loxapine derivatives against intracellular multidrug-resistant bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 4.98 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.82 |
| CHEMBL5171589 | — | — | 1 | 6.41 |
| CHEMBL5193050 | — | — | 1 | 5.95 |
| CHEMBL5205143 | — | — | 1 | 5.95 |
| CHEMBL5197853 | — | — | 1 | 5.91 |
| CHEMBL5201768 | — | — | 1 | 5.44 |
| CHEMBL5195489 | — | — | 1 | 5.36 |
| CHEMBL5184368 | — | — | 1 | 5.31 |
| CHEMBL1113 | AMOXAPINE | 4.0 | 1 | 5.14 |
| CHEMBL5173377 | — | — | 1 | 4.73 |
| CHEMBL5187960 | — | — | 1 | 4.71 |
| CHEMBL5181307 | — | — | 1 | 4.67 |
| CHEMBL5205507 | — | — | 1 | 4.54 |
| CHEMBL5184013 | — | — | 1 | 4.51 |
| CHEMBL5169474 | — | — | 1 | 4.50 |
| CHEMBL5202476 | — | — | 1 | 4.47 |
| CHEMBL5180967 | — | — | 1 | 4.42 |
| CHEMBL5204272 | — | — | 1 | 4.36 |
| CHEMBL5206629 | — | — | 1 | 4.34 |
| CHEMBL5194801 | — | — | 1 | 4.27 |
| CHEMBL5181974 | — | — | 1 | 4.27 |
| CHEMBL5173496 | — | — | 1 | 4.26 |
| CHEMBL5198752 | — | — | 1 | 4.25 |
| CHEMBL5184509 | — | — | 1 | - |
| CHEMBL5197577 | — | — | 1 | - |
| CHEMBL1650595 | AR-12 | 1.0 | 1 | - |
| CHEMBL5182146 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5171589 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5193050 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5205143 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5197853 | — | EC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5201768 | — | EC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL5195489 | — | EC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL5184368 | — | EC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL1113 | AMOXAPINE | EC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL5173377 | — | EC50 | = | 18510.0 | nM | 4.73 |
| CHEMBL5187960 | — | EC50 | = | 19660.0 | nM | 4.71 |
| CHEMBL5181307 | — | EC50 | = | 21230.0 | nM | 4.67 |
| CHEMBL5205507 | — | EC50 | = | 28510.0 | nM | 4.54 |
| CHEMBL5184013 | — | EC50 | = | 31080.0 | nM | 4.51 |
| CHEMBL5169474 | — | EC50 | = | 31980.0 | nM | 4.50 |
| CHEMBL5202476 | — | EC50 | = | 33510.0 | nM | 4.47 |
| CHEMBL5180967 | — | EC50 | = | 38170.0 | nM | 4.42 |
| CHEMBL5204272 | — | EC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL5206629 | — | EC50 | = | 45160.0 | nM | 4.34 |
| CHEMBL5194801 | — | EC50 | = | 53460.0 | nM | 4.27 |
| CHEMBL5181974 | — | EC50 | = | 54110.0 | nM | 4.27 |
| CHEMBL5173496 | — | EC50 | = | 55110.0 | nM | 4.26 |
| CHEMBL5198752 | — | EC50 | = | 55970.0 | nM | 4.25 |
| CHEMBL5184509 | — | EC50 | > | 90000.0 | nM | - |
| CHEMBL5197577 | — | EC50 | > | 90000.0 | nM | - |
| CHEMBL1650595 | AR-12 | EC50 | - | — | - | |
| CHEMBL5182146 | — | EC50 | - | — | - |