Assay Detail
Binding
CHEMBL5108905
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Irreversible inhibition of recombinant Staphylococcus aureus sortase A deltaN24 expressed in Escherichia coli BL21(DE3) cells using Abz-LPATG-Dnp as substrate assessed as inactivation constant preincubated for 60 mins followed by substrate addition and measured every 1 min for 15 mins by fluorescence intensity based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Covalent sortase A inhibitor ML346 prevents <i>Staphylococcus aureus</i> infection of <i>Galleria mellonella</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 5.61 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174805 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174805 | — | Ki | = | 2453.0 | nM | 5.61 |