Assay Detail
Binding
CHEMBL5108914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cathepsin L (unknown origin) using Cbz-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 10 mins by fluorometric assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Covalent sortase A inhibitor ML346 prevents <i>Staphylococcus aureus</i> infection of <i>Galleria mellonella</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.64 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374508 | E-64 | — | 1 | 8.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374508 | E-64 | IC50 | = | 2.3 | nM | 8.64 |