Assay Detail
Binding
CHEMBL5108949
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Inhibition of wild type Abl (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The progress of small-molecules and degraders against BCR-ABL for the treatment of CML.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.42 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1738757 | REBASTINIB | 2.0 | 1 | 9.10 |
| CHEMBL3545085 | XL-228 | 1.0 | 1 | 8.30 |
| CHEMBL1908397 | KW-2449 | 1.0 | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1738757 | REBASTINIB | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3545085 | XL-228 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1908397 | KW-2449 | IC50 | = | 14.0 | nM | 7.85 |