Assay Detail
Binding
CHEMBL5109043
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Degradation of ER alpha in human MCF7 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cascade synthetic strategies opening access to medicinal-relevant aliphatic 3- and 4-membered N-heterocyclic scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.42 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4455953 | — | — | 1 | 10.30 |
| CHEMBL4447340 | — | — | 1 | 10.00 |
| CHEMBL4524752 | — | — | 1 | 9.52 |
| CHEMBL4456532 | — | — | 1 | 9.38 |
| CHEMBL4452393 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4455953 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL4447340 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4524752 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4456532 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL4452393 | — | IC50 | = | 13.0 | nM | 7.89 |