Assay Detail
Binding
CHEMBL5109367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TRKA (unknown origin) in presence of [gamma33P]ATP by radiometric HotSpot assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and structural analysis of a selective tropomyosin receptor kinase C (TRKC) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.60 | 8.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3889654 | LAROTRECTINIB | 4.0 | 1 | 8.71 |
| CHEMBL3891994 | — | — | 1 | 8.00 |
| CHEMBL4456471 | — | — | 1 | 6.36 |
| CHEMBL4473123 | — | — | 1 | 6.21 |
| CHEMBL4470728 | — | — | 1 | 6.19 |
| CHEMBL4571608 | — | — | 1 | 5.93 |
| CHEMBL5198364 | — | — | 1 | 5.85 |
| CHEMBL4440687 | — | — | 1 | 5.58 |
| CHEMBL4437322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3889654 | LAROTRECTINIB | IC50 | = | 1.96 | nM | 8.71 |
| CHEMBL3891994 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4456471 | — | IC50 | = | 432.1 | nM | 6.36 |
| CHEMBL4473123 | — | IC50 | = | 622.6 | nM | 6.21 |
| CHEMBL4470728 | — | IC50 | = | 648.6 | nM | 6.19 |
| CHEMBL4571608 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL5198364 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4440687 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL4437322 | — | IC50 | > | 5000.0 | nM | - |