Assay Detail
Functional
CHEMBL5109447
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Anti-ferroptotic activity against Erastin-induced ferroptosis in human HT-1080 cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 7.81 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201614 | — | — | 1 | 9.00 |
| CHEMBL5176315 | — | — | 1 | 9.00 |
| CHEMBL5175037 | — | — | 1 | 8.52 |
| CHEMBL5195940 | — | — | 1 | 8.52 |
| CHEMBL5198622 | — | — | 1 | 8.40 |
| CHEMBL5192918 | — | — | 1 | 8.10 |
| CHEMBL5203003 | — | — | 1 | 8.00 |
| CHEMBL5192955 | — | — | 1 | 7.96 |
| CHEMBL5199668 | — | — | 1 | 7.89 |
| CHEMBL5208922 | — | — | 1 | 7.77 |
| CHEMBL5197158 | — | — | 1 | 7.72 |
| CHEMBL5180505 | — | — | 1 | 7.70 |
| CHEMBL5181332 | — | — | 1 | 7.68 |
| CHEMBL5177579 | — | — | 1 | 7.60 |
| CHEMBL5190111 | — | — | 1 | 7.58 |
| CHEMBL5177902 | — | — | 1 | 7.54 |
| CHEMBL5170289 | — | — | 1 | 7.48 |
| CHEMBL5200559 | — | — | 1 | 7.43 |
| CHEMBL5170133 | — | — | 1 | 7.41 |
| CHEMBL5172974 | — | — | 1 | 7.41 |
| CHEMBL5206555 | — | — | 1 | 7.40 |
| CHEMBL5202118 | — | — | 1 | 7.39 |
| CHEMBL5173680 | — | — | 1 | 7.38 |
| CHEMBL5186691 | — | — | 1 | 7.24 |
| CHEMBL5174175 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201614 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5176315 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5175037 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5195940 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5198622 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5192918 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5203003 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5192955 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5199668 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5208922 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5197158 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5180505 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5181332 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5177579 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5190111 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5177902 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5170289 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5200559 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5170133 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5172974 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5206555 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5202118 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5173680 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5186691 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5174175 | — | EC50 | = | 89.0 | nM | 7.05 |