Assay Detail
Functional
CHEMBL5109652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H446 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H446 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.06 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 11.00 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 9.41 |
| CHEMBL5202359 | — | — | 1 | 9.11 |
| CHEMBL307794 | — | — | 1 | 8.05 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481 | IRINOTECAN | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL5202359 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL307794 | — | IC50 | = | 8.87 | nM | 8.05 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 17.59 | nM | 7.75 |