Assay Detail
Functional
CHEMBL5109840
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Antiviral activity against HSV-2 G strain infected in HEL cells assessed as reduction in virus-induced cytopathic effect by microscopic analysis
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 2 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.69 | 7.70 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 7.70 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.40 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 6.00 |
| CHEMBL5180013 | — | — | 1 | 4.35 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 4.02 |
| CHEMBL5188305 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5180013 | — | EC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL5188305 | — | Activity | - | — | - |