Assay Detail
Binding
CHEMBL5111285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferase reporter gene assay
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr<sup>705</sup>/Ser<sup>727</sup> Inhibitory Activity for Gastric Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 6.81 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5176684 | — | — | 1 | 7.56 |
| CHEMBL5176948 | — | — | 1 | 7.49 |
| CHEMBL5182844 | — | — | 1 | 7.43 |
| CHEMBL5199234 | — | — | 1 | 7.40 |
| CHEMBL5185530 | — | — | 1 | 7.40 |
| CHEMBL5196490 | — | — | 1 | 7.28 |
| CHEMBL5189947 | — | — | 1 | 7.24 |
| CHEMBL5170615 | — | — | 1 | 7.22 |
| CHEMBL5182625 | — | — | 1 | 7.20 |
| CHEMBL5171708 | — | — | 1 | 7.12 |
| CHEMBL5177332 | — | — | 1 | 7.05 |
| CHEMBL5189774 | — | — | 1 | 7.03 |
| CHEMBL5183263 | — | — | 1 | 7.03 |
| CHEMBL5199713 | — | — | 1 | 6.96 |
| CHEMBL5200334 | — | — | 1 | 6.95 |
| CHEMBL5189465 | — | — | 1 | 6.95 |
| CHEMBL5189640 | — | — | 1 | 6.91 |
| CHEMBL5204997 | — | — | 1 | 6.89 |
| CHEMBL5175537 | — | — | 1 | 6.83 |
| CHEMBL5182268 | — | — | 1 | 6.78 |
| CHEMBL5196843 | — | — | 1 | 6.76 |
| CHEMBL5199802 | — | — | 1 | 6.75 |
| CHEMBL5191059 | — | — | 1 | 6.74 |
| CHEMBL5204672 | — | — | 1 | 6.59 |
| CHEMBL5190384 | — | — | 1 | 6.57 |
| CHEMBL5189435 | — | — | 1 | 6.56 |
| CHEMBL5208052 | — | — | 1 | 6.53 |
| CHEMBL5199392 | — | — | 1 | 6.52 |
| CHEMBL5191928 | — | — | 1 | 6.51 |
| CHEMBL5205208 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5176684 | — | IC50 | = | 27.8 | nM | 7.56 |
| CHEMBL5176948 | — | IC50 | = | 32.3 | nM | 7.49 |
| CHEMBL5182844 | — | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL5199234 | — | IC50 | = | 40.2 | nM | 7.40 |
| CHEMBL5185530 | — | IC50 | = | 40.2 | nM | 7.40 |
| CHEMBL5196490 | — | IC50 | = | 52.1 | nM | 7.28 |
| CHEMBL5189947 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5170615 | — | IC50 | = | 60.2 | nM | 7.22 |
| CHEMBL5182625 | — | IC50 | = | 63.6 | nM | 7.20 |
| CHEMBL5171708 | — | IC50 | = | 75.9 | nM | 7.12 |
| CHEMBL5177332 | — | IC50 | = | 88.1 | nM | 7.05 |
| CHEMBL5189774 | — | IC50 | = | 93.2 | nM | 7.03 |
| CHEMBL5183263 | — | IC50 | = | 94.1 | nM | 7.03 |
| CHEMBL5199713 | — | IC50 | = | 108.5 | nM | 6.96 |
| CHEMBL5189465 | — | IC50 | = | 113.3 | nM | 6.95 |
| CHEMBL5200334 | — | IC50 | = | 112.7 | nM | 6.95 |
| CHEMBL5189640 | — | IC50 | = | 123.3 | nM | 6.91 |
| CHEMBL5204997 | — | IC50 | = | 129.7 | nM | 6.89 |
| CHEMBL5175537 | — | IC50 | = | 147.5 | nM | 6.83 |
| CHEMBL5182268 | — | IC50 | = | 167.3 | nM | 6.78 |
| CHEMBL5196843 | — | IC50 | = | 172.7 | nM | 6.76 |
| CHEMBL5199802 | — | IC50 | = | 177.4 | nM | 6.75 |
| CHEMBL5191059 | — | IC50 | = | 181.9 | nM | 6.74 |
| CHEMBL5204672 | — | IC50 | = | 257.5 | nM | 6.59 |
| CHEMBL5190384 | — | IC50 | = | 270.5 | nM | 6.57 |
| CHEMBL5189435 | — | IC50 | = | 272.9 | nM | 6.56 |
| CHEMBL5208052 | — | IC50 | = | 295.7 | nM | 6.53 |
| CHEMBL5199392 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL5191928 | — | IC50 | = | 305.6 | nM | 6.51 |
| CHEMBL5205208 | — | IC50 | = | 325.4 | nM | 6.49 |
| CHEMBL5208462 | — | IC50 | = | 358.9 | nM | 6.45 |
| CHEMBL5189395 | — | IC50 | = | 476.9 | nM | 6.32 |
| CHEMBL5175861 | — | IC50 | = | 515.7 | nM | 6.29 |
| CHEMBL5191288 | — | IC50 | = | 533.2 | nM | 6.27 |
| CHEMBL5186501 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL5207761 | — | IC50 | = | 802.5 | nM | 6.10 |
| CHEMBL5186045 | — | IC50 | = | 2792.1 | nM | 5.55 |
| CHEMBL5177779 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5202700 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5189463 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5202773 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5178453 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5203423 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5184061 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5189078 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5169556 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5193929 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5203071 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5189121 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL64130 | NAPABUCASIN | IC50 | - | — | - |