Assay Detail
Binding
CHEMBL5111458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for 60 mins in presence of ATP by ADP-Glo assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
1-phosphatidylinositol 3-phosphate 5-kinase (CHEMBL1938222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.69 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178735 | — | — | 1 | 9.09 |
| CHEMBL5189479 | — | — | 1 | 8.74 |
| CHEMBL5193848 | — | — | 1 | 8.72 |
| CHEMBL2334586 | — | — | 1 | 8.66 |
| CHEMBL4297643 | APILIMOD | 2.0 | 1 | 8.47 |
| CHEMBL4303292 | — | — | 1 | 8.43 |
| CHEMBL5181163 | — | — | 1 | 8.21 |
| CHEMBL5198944 | — | — | 1 | 8.21 |
| CHEMBL5174830 | — | — | 1 | 8.16 |
| CHEMBL5207387 | — | — | 1 | 8.09 |
| CHEMBL5171753 | — | — | 1 | 8.03 |
| CHEMBL5190524 | — | — | 1 | 7.66 |
| CHEMBL5188159 | — | — | 1 | 7.58 |
| CHEMBL5200109 | — | — | 1 | 7.47 |
| CHEMBL5202422 | — | — | 1 | 7.21 |
| CHEMBL5190724 | — | — | 1 | 7.12 |
| CHEMBL5192827 | — | — | 1 | 7.11 |
| CHEMBL5184182 | — | — | 1 | 6.85 |
| CHEMBL5203403 | — | — | 1 | 6.54 |
| CHEMBL5190455 | — | — | 1 | 6.37 |
| CHEMBL5204874 | — | — | 1 | 6.24 |
| CHEMBL5199026 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178735 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL5189479 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5193848 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL2334586 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4297643 | APILIMOD | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4303292 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5181163 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5198944 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5174830 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5207387 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL5171753 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL5190524 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5188159 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5200109 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5202422 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5190724 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5192827 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL5184182 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5203403 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5190455 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5204874 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5199026 | — | IC50 | = | 720.0 | nM | 6.14 |