Assay Detail
Binding
CHEMBL5111476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length human KDM5B expressed in baculovirus expression system using (ARTK(me3)QTARKSTGGKAPRKQLA peptide subst
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Pyrazole-Based KDM5B Inhibitor <b>TK</b>-<b>129</b> and Its Protective Effects on Myocardial Remodeling and Fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.61 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786952 | — | — | 1 | 8.70 |
| CHEMBL4454253 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786952 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4454253 | — | IC50 | = | 3.0 | nM | 8.52 |