Assay Detail
Binding
CHEMBL5111622
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Binding affinity to recombinant LIMK1 (330 to 637 residues) (unknown origin) expressed in baculovirus infected insect cells assessed as dissociation constant at 10 uM by isothermal titration calorimetry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.98 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355507 | — | — | 1 | 7.28 |
| CHEMBL4790618 | — | — | 1 | 7.19 |
| CHEMBL5184281 | — | — | 1 | 7.05 |
| CHEMBL5186508 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355507 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL4790618 | — | Kd | = | 64.0 | nM | 7.19 |
| CHEMBL5184281 | — | Kd | = | 89.0 | nM | 7.05 |
| CHEMBL5186508 | — | Kd | = | 386.0 | nM | 6.41 |