Assay Detail
Binding
CHEMBL5111629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to LIMK1 in human HeLa cells assessed as apparent dissociation constant incubated for 45 mins by kinobead based pulldown assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.72 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2141887 | — | — | 1 | 7.23 |
| CHEMBL5169387 | — | — | 1 | 6.75 |
| CHEMBL4790618 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2141887 | — | Kd | = | 59.0 | nM | 7.23 |
| CHEMBL5169387 | — | Kd | = | 177.0 | nM | 6.75 |
| CHEMBL4790618 | — | Kd | = | 682.0 | nM | 6.17 |