Assay Detail
Functional
CHEMBL5111872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Histone Deacetylase and Enhancer of Zeste Homologue 2 Dual Inhibitors Presenting a Synergistic Effect for the Treatment of Hematological Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.52 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5189365 | — | — | 1 | 6.29 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.27 |
| CHEMBL5205080 | — | — | 1 | 6.07 |
| CHEMBL5188854 | — | — | 1 | 6.02 |
| CHEMBL5184172 | — | — | 1 | 5.91 |
| CHEMBL5173660 | — | — | 1 | 5.91 |
| CHEMBL5191470 | — | — | 1 | 5.84 |
| CHEMBL5200979 | — | — | 1 | 5.78 |
| CHEMBL5174790 | — | — | 1 | 5.73 |
| CHEMBL5197618 | — | — | 1 | 5.69 |
| CHEMBL5177842 | — | — | 1 | 5.66 |
| CHEMBL5182624 | — | — | 1 | 5.59 |
| CHEMBL5187019 | — | — | 1 | 5.54 |
| CHEMBL5192423 | — | — | 1 | 5.08 |
| CHEMBL5193584 | — | — | 1 | 4.95 |
| CHEMBL5176169 | — | — | 1 | 4.92 |
| CHEMBL5186225 | — | — | 1 | 4.85 |
| CHEMBL5174084 | — | — | 1 | 4.84 |
| CHEMBL5177261 | — | — | 1 | 4.75 |
| CHEMBL5183275 | — | — | 1 | 4.74 |
| CHEMBL4532174 | — | — | 1 | - |
| CHEMBL3414621 | TAZEMETOSTAT | 4.0 | 1 | - |
| CHEMBL5201866 | — | — | 1 | - |
| CHEMBL5192032 | — | — | 1 | - |
| CHEMBL5171670 | — | — | 1 | - |
| CHEMBL5177731 | — | — | 1 | - |
| CHEMBL5208164 | — | — | 1 | - |
| CHEMBL5173482 | — | — | 1 | - |
| CHEMBL5169646 | — | — | 1 | - |
| CHEMBL5196140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5189365 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5205080 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5188854 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5184172 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5173660 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5191470 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL5200979 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL5174790 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL5197618 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL5177842 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL5182624 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL5187019 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL5192423 | — | IC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL5193584 | — | IC50 | = | 11210.0 | nM | 4.95 |
| CHEMBL5176169 | — | IC50 | = | 11980.0 | nM | 4.92 |
| CHEMBL5186225 | — | IC50 | = | 14220.0 | nM | 4.85 |
| CHEMBL5174084 | — | IC50 | = | 14470.0 | nM | 4.84 |
| CHEMBL5177261 | — | IC50 | = | 17830.0 | nM | 4.75 |
| CHEMBL5183275 | — | IC50 | = | 18320.0 | nM | 4.74 |
| CHEMBL4532174 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3414621 | TAZEMETOSTAT | IC50 | > | 20000.0 | nM | - |
| CHEMBL5201866 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5192032 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5171670 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5177731 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5208164 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5173482 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5169646 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5196140 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5178386 | — | IC50 | > | 20000.0 | nM | - |