Assay Detail
Functional
CHEMBL5112766
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against MERS-CoV EMC2012 infected in HEK293T cells transfected with DPP4 assessed as inhibition of virus induced cytopathic effect incubated for 2 to 3 days by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Middle East respiratory syndrome-related coronavirus |
| Cell Type | HEK293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Middle East respiratory syndrome-related coronavirus (CHEMBL4296578) ↗| Type | ORGANISM |
| Organism | Middle East respiratory syndrome-related coronavirus |
Publication
Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.26 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5179778 | — | — | 1 | 8.33 |
| CHEMBL5198073 | — | — | 1 | 8.30 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 7.61 |
| CHEMBL4777223 | PF-00835231 | -1.0 | 1 | 6.16 |
| CHEMBL2178720 | N-HYDROXYCYTIDINE | -1.0 | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5179778 | — | EC50 | = | 4.72 | nM | 8.33 |
| CHEMBL5198073 | — | EC50 | = | 5.01 | nM | 8.30 |
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 24.3 | nM | 7.61 |
| CHEMBL4777223 | PF-00835231 | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2178720 | N-HYDROXYCYTIDINE | EC50 | = | 1318.0 | nM | 5.88 |