Assay Detail
Functional
CHEMBL5113217
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.68 | 4.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15060 | — | — | 1 | 4.78 |
| CHEMBL5186032 | — | — | 1 | 4.68 |
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15060 | — | EC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL5186032 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL10878 | AGOMELATINE | EC50 | = | 26500.0 | nM | 4.58 |