Assay Detail
Binding
CHEMBL5113280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Axl using KKSRGDYMTMQIG as substrate incubated for 40 mins in the presence of [gamma33P]ATP by scintillation counting analysis
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based discovery of potent inhibitors of Axl: design, synthesis, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.61 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5184642 | — | — | 1 | 8.30 |
| CHEMBL5185599 | — | — | 1 | 8.30 |
| CHEMBL5187900 | — | — | 1 | 8.10 |
| CHEMBL5201640 | — | — | 1 | 8.05 |
| CHEMBL5171253 | — | — | 1 | 8.00 |
| CHEMBL5192037 | — | — | 1 | 8.00 |
| CHEMBL5169760 | — | — | 1 | 7.96 |
| CHEMBL5187688 | — | — | 1 | 7.96 |
| CHEMBL5204838 | — | — | 1 | 7.92 |
| CHEMBL5180366 | — | — | 1 | 7.92 |
| CHEMBL5197492 | — | — | 1 | 7.92 |
| CHEMBL5189859 | — | — | 1 | 7.85 |
| CHEMBL5186349 | — | — | 1 | 7.85 |
| CHEMBL5209500 | — | — | 1 | 7.82 |
| CHEMBL2022968 | DUBERMATINIB | 2.0 | 1 | 7.82 |
| CHEMBL5209264 | — | — | 1 | 7.82 |
| CHEMBL5178768 | — | — | 1 | 7.80 |
| CHEMBL5199302 | — | — | 1 | 7.80 |
| CHEMBL5173201 | — | — | 1 | 7.77 |
| CHEMBL5203409 | — | — | 1 | 7.75 |
| CHEMBL5179008 | — | — | 1 | 7.66 |
| CHEMBL5205244 | — | — | 1 | 7.66 |
| CHEMBL5177979 | — | — | 1 | 7.64 |
| CHEMBL5187223 | — | — | 1 | 7.60 |
| CHEMBL5195687 | — | — | 1 | 7.55 |
| CHEMBL5175081 | — | — | 1 | 7.52 |
| CHEMBL5207577 | — | — | 1 | 7.52 |
| CHEMBL5176724 | — | — | 1 | 7.52 |
| CHEMBL5189203 | — | — | 1 | 7.44 |
| CHEMBL5173543 | — | — | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5184642 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5185599 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5187900 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5201640 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5171253 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5192037 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5169760 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5187688 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5204838 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5180366 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5197492 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5189859 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5186349 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5209264 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2022968 | DUBERMATINIB | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5209500 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5178768 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5199302 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5173201 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5203409 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5179008 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5205244 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5177979 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5187223 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5195687 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5175081 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5207577 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5176724 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5189203 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5173543 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5187989 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5204819 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5170873 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5202025 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5195675 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5183041 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5183908 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL5183492 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL5197239 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL5169769 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL5192078 | — | IC50 | - | — | - |