Assay Detail
Binding
CHEMBL5113356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hematopoietic prostaglandin D synthase (CHEMBL5879) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D<sub>2</sub> synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.87 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5193611 | — | — | 1 | 7.11 |
| CHEMBL5076100 | — | — | 1 | 6.93 |
| CHEMBL5207946 | — | — | 1 | 6.91 |
| CHEMBL3650200 | — | — | 1 | 6.87 |
| CHEMBL5200341 | — | — | 1 | 6.71 |
| CHEMBL4238186 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5193611 | — | IC50 | = | 78.1 | nM | 7.11 |
| CHEMBL5076100 | — | IC50 | = | 116.5 | nM | 6.93 |
| CHEMBL5207946 | — | IC50 | = | 123.9 | nM | 6.91 |
| CHEMBL3650200 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL5200341 | — | IC50 | = | 196.3 | nM | 6.71 |
| CHEMBL4238186 | — | IC50 | = | 211.2 | nM | 6.67 |