Assay Detail
Binding
CHEMBL5113783
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 150 mins by liquid scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Research progress in biological activities of isochroman derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.83 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138809 | — | — | 1 | 8.94 |
| CHEMBL141209 | — | — | 1 | 8.89 |
| CHEMBL148276 | — | — | 1 | 8.81 |
| CHEMBL141743 | — | — | 1 | 8.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138809 | — | Ki | = | 1.14 | nM | 8.94 |
| CHEMBL141209 | — | Ki | = | 1.29 | nM | 8.89 |
| CHEMBL148276 | — | Ki | = | 1.54 | nM | 8.81 |
| CHEMBL141743 | — | Ki | = | 2.07 | nM | 8.68 |