Assay Detail
Binding
CHEMBL5113824
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Inhibition of Mcl-1/Bid (unknown origin) by fluorescence polarization assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist (CHEMBL3430886) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.98 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1272170 | — | — | 1 | 7.60 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 5.76 |
| CHEMBL5207007 | — | — | 1 | 5.61 |
| CHEMBL5193844 | — | — | 1 | 5.60 |
| CHEMBL3265288 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1272170 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL51483 | GOSSYPOL | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL5207007 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL5193844 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL3265288 | — | IC50 | = | 4700.0 | nM | 5.33 |