Assay Detail
Binding
CHEMBL5113859
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Inhibition of Mcl-1/Bak (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.47 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539481 | — | — | 1 | 6.64 |
| CHEMBL5203189 | — | — | 1 | 6.55 |
| CHEMBL5182721 | — | — | 1 | 6.21 |
| CHEMBL1269107 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539481 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5203189 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5182721 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1269107 | — | IC50 | = | 122000.0 | nM | - |