Assay Detail
Binding
CHEMBL5113870
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Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.57 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4160782 | — | — | 1 | 6.92 |
| CHEMBL5198484 | — | — | 1 | 6.82 |
| CHEMBL4167501 | — | — | 1 | 5.54 |
| CHEMBL605114 | — | — | 1 | 5.16 |
| CHEMBL5207001 | — | — | 1 | 5.11 |
| CHEMBL596599 | — | — | 1 | 5.10 |
| CHEMBL335265 | — | — | 1 | 4.36 |
| CHEMBL5170330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4160782 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL5198484 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL4167501 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL605114 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL5207001 | — | Ki | = | 7770.0 | nM | 5.11 |
| CHEMBL596599 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL335265 | — | Ki | = | 44000.0 | nM | 4.36 |
| CHEMBL5170330 | — | Ki | = | 261000.0 | nM | - |