Assay Detail
Binding
CHEMBL5113872
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Binding affinity to Mcl-1/Bak (unknown origin) assessed as dissociation constant by ITC method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.23 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL605114 | — | — | 1 | 6.60 |
| CHEMBL596599 | — | — | 1 | 5.00 |
| CHEMBL335265 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL605114 | — | Kd | = | 250.0 | nM | 6.60 |
| CHEMBL596599 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL335265 | — | Kd | = | 84000.0 | nM | 4.08 |