Assay Detail
Binding
CHEMBL5113877
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Binding affinity to Bcl-2 /Bid (unknown origin) assessed as inhibition constant by fluorescence polarization assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.16 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4848284 | — | — | 1 | 6.51 |
| CHEMBL5204188 | — | — | 1 | 6.27 |
| CHEMBL5199461 | — | — | 1 | 6.23 |
| CHEMBL5203252 | — | — | 1 | 6.09 |
| CHEMBL5183108 | — | — | 1 | 6.03 |
| CHEMBL5206049 | — | — | 1 | 6.00 |
| CHEMBL5181865 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4848284 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL5204188 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL5199461 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL5203252 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL5183108 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL5206049 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL5181865 | — | Ki | = | 1100.0 | nM | 5.96 |