Assay Detail
Binding
CHEMBL5113891
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Binding affinity to Bcl-2/Bid (unknown origin) by fluorescence polarization assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.16 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5090868 | — | — | 1 | 5.92 |
| CHEMBL5196159 | — | — | 1 | 5.72 |
| CHEMBL5183781 | — | — | 1 | 5.62 |
| CHEMBL5186810 | — | — | 1 | 4.82 |
| CHEMBL3265291 | — | — | 1 | 4.62 |
| CHEMBL2030270 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5090868 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL5196159 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL5183781 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL5186810 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL3265291 | — | Ki | = | 23830.0 | nM | 4.62 |
| CHEMBL2030270 | — | Ki | = | 54650.0 | nM | 4.26 |