Assay Detail
Binding
CHEMBL5113897
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Binding affinity to Mcl-1/Bid (unknown origin) by fluorescence polarization assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist (CHEMBL3430886) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.88 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5090868 | — | — | 1 | 6.48 |
| CHEMBL5186810 | — | — | 1 | 6.28 |
| CHEMBL5183781 | — | — | 1 | 5.70 |
| CHEMBL5196159 | — | — | 1 | 5.66 |
| CHEMBL4161959 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5090868 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL5186810 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL5183781 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL5196159 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL4161959 | — | Ki | = | 5200.0 | nM | 5.28 |