Assay Detail
Binding
CHEMBL5114020
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Inhibition of telomerase derived from human K562 cell extract incubated for 30 mins by TRAP assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.00 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219728 | — | — | 1 | 6.36 |
| CHEMBL225340 | — | — | 1 | 6.26 |
| CHEMBL222205 | — | — | 1 | 5.95 |
| CHEMBL376497 | — | — | 1 | 5.81 |
| CHEMBL222885 | — | — | 1 | 5.63 |
| CHEMBL224248 | QUINDOLINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219728 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL225340 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL222205 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL376497 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL222885 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL224248 | QUINDOLINE | IC50 | > | 138000.0 | nM | - |