Compound Detail
CHEMBL225340
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Basic Information
| ChEMBL ID | CHEMBL225340 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LBANEDOFRZCTHP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
346.4
MW (Da)
3.61
ALogP
4
HBA
2
HBD
53.2
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 6.26 | 6.26 | 550.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.26 | 6.26 | 550.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 550.0 | nM | 6.26 | Inhibition of telomerase by TRAP assay | 16279791 |
| Telomerase reverse transcriptase | IC50 | = | 550.0 | nM | 6.26 | Inhibition of telomerase derived from human K562 cell extract incubated for 30 m... | 34710743 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16279791 | 10.1021/jm050041b | Unchecked | 5 |
| 16279791 | 10.1021/jm050041b | No relevant target | 1 |
| 34710743 | 10.1016/j.ejmech.2021.113938 | Telomerase reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine