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Assay Detail

CHEMBL914883

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Binding
Inhibition of telomerase by TRAP assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase.
Zhou JL, Lu YJ, Ou TM, Zhou JM, Huang ZS, Zhu XF, Du CJ, Bu XZ, Ma L, Gu LQ, Li YM, Chan AS.
J Med Chem (2005) 48 : 7315 -7321
PubMed 16279791 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.60 6.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL219728 1 6.36
CHEMBL225340 1 6.26
CHEMBL222205 1 5.95
CHEMBL376497 1 5.81
CHEMBL222885 1 5.63
CHEMBL376078 1 5.48
CHEMBL388603 1 5.36
CHEMBL223184 1 5.15
CHEMBL220000 1 5.09
CHEMBL222886 1 4.91
CHEMBL224248 QUINDOLINE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL219728 IC50 = 440.0 nM 6.36
CHEMBL225340 IC50 = 550.0 nM 6.26
CHEMBL222205 IC50 = 1120.0 nM 5.95
CHEMBL376497 IC50 = 1550.0 nM 5.81
CHEMBL222885 IC50 = 2350.0 nM 5.63
CHEMBL376078 IC50 = 3290.0 nM 5.48
CHEMBL388603 IC50 = 4380.0 nM 5.36
CHEMBL223184 IC50 = 7110.0 nM 5.15
CHEMBL220000 IC50 = 8120.0 nM 5.09
CHEMBL222886 IC50 = 12300.0 nM 4.91
CHEMBL224248 QUINDOLINE IC50 > 138000.0 nM -