Assay Detail
Toxicity
CHEMBL5114056
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Cytotoxicity against rat L6 cells assessed as cell growth inhibition
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.93 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2391249 | — | — | 1 | 6.66 |
| CHEMBL3585413 | — | — | 1 | 6.56 |
| CHEMBL2058009 | — | — | 1 | 6.55 |
| CHEMBL2391246 | — | — | 1 | 6.47 |
| CHEMBL599054 | — | — | 1 | 6.20 |
| CHEMBL2322213 | — | — | 1 | 5.96 |
| CHEMBL5175787 | — | — | 1 | 5.93 |
| CHEMBL2322216 | — | — | 1 | 5.91 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 5.50 |
| CHEMBL5180513 | — | — | 1 | 5.49 |
| CHEMBL2322509 | — | — | 1 | 5.45 |
| CHEMBL5181218 | — | — | 1 | 5.25 |
| CHEMBL5208279 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2391249 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL3585413 | — | IC50 | = | 275.5 | nM | 6.56 |
| CHEMBL2058009 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL2391246 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL599054 | — | IC50 | = | 626.8 | nM | 6.20 |
| CHEMBL2322213 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5175787 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL2322216 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL5180513 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL2322509 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL5181218 | — | IC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL5208279 | — | IC50 | = | 7250.0 | nM | 5.14 |