Assay Detail
Binding
CHEMBL5114057
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Inhibition of beta-hematin formation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.72 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 5.22 |
| CHEMBL5175787 | — | — | 1 | 5.00 |
| CHEMBL3585413 | — | — | 1 | 4.77 |
| CHEMBL5208279 | — | — | 1 | 4.70 |
| CHEMBL5181218 | — | — | 1 | 4.58 |
| CHEMBL5180513 | — | — | 1 | 4.47 |
| CHEMBL2391249 | — | — | 1 | 4.31 |
| CHEMBL2391246 | — | — | 1 | - |
| CHEMBL599054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL5175787 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3585413 | — | IC50 | = | 16820.0 | nM | 4.77 |
| CHEMBL5208279 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL5181218 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL5180513 | — | IC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL2391249 | — | IC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL2391246 | — | IC50 | = | 104400.0 | nM | - |
| CHEMBL599054 | — | IC50 | = | 626800.0 | nM | - |