Assay Detail
Binding
CHEMBL5114136
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Inhibition of EGFR L858R mutant (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.65 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5208825 | — | — | 1 | 7.12 |
| CHEMBL5206400 | — | — | 1 | 7.08 |
| CHEMBL5192318 | — | — | 1 | 7.06 |
| CHEMBL4531109 | — | — | 1 | 5.35 |
| CHEMBL4795574 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5208825 | — | IC50 | = | 75.42 | nM | 7.12 |
| CHEMBL5206400 | — | IC50 | = | 82.76 | nM | 7.08 |
| CHEMBL5192318 | — | IC50 | = | 87.34 | nM | 7.06 |
| CHEMBL4531109 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4795574 | — | IC50 | > | 10000.0 | nM | - |