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Assay Detail

CHEMBL5114201

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to AMPA receptor (unknown origin)
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Glutamate receptor ionotropic AMPA (CHEMBL2096670)
Type PROTEIN COMPLEX GROUP
Organism Homo sapiens

Publication

Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.
Jiang X, Wu K, Bai R, Zhang P, Zhang Y.
Eur J Med Chem (2022) 229 : 114085 -114085
PubMed 34998058 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.15 6.32
Ki 3 7.16 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL188018 1 7.80
CHEMBL116565 1 7.66
CHEMBL5186117 1 6.32
CHEMBL5193862 1 6.02
CHEMBL5198336 1 4.62
CHEMBL5174264 1 4.52
CHEMBL5179605 1 -
CHEMBL5187440 1 -
CHEMBL5199355 1 -
CHEMBL1375097 1 -
CHEMBL5195778 1 -
CHEMBL5190991 1 -
CHEMBL5208673 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL188018 Ki = 16.0 nM 7.80
CHEMBL116565 Ki = 22.0 nM 7.66
CHEMBL5186117 IC50 = 480.0 nM 6.32
CHEMBL5193862 Ki = 960.0 nM 6.02
CHEMBL5198336 IC50 = 24000.0 nM 4.62
CHEMBL5174264 IC50 = 30000.0 nM 4.52
CHEMBL5179605 IC50 > 100000.0 nM -
CHEMBL5187440 IC50 > 100000.0 nM -
CHEMBL5199355 IC50 > 100000.0 nM -
CHEMBL1375097 IC50 > 100000.0 nM -
CHEMBL5195778 IC50 > 100000.0 nM -
CHEMBL5190991 IC50 > 100000.0 nM -
CHEMBL5208673 IC50 > 100000.0 nM -