Compound Detail
CHEMBL5208673
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Basic Information
| ChEMBL ID | CHEMBL5208673 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LEHAVESJYADTSX-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
282.2
MW (Da)
1.58
ALogP
3
HBA
3
HBD
103.0
PSA (Ų)
0.62
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 5.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 3 CHEMBL3684 | Ki | 5.18 | 5.18 | 6600.0 | 1 |
| Glutamate receptor ionotropic, kainate 1 CHEMBL1918 | Ki | 4.57 | 4.57 | 27000.0 | 1 |
| Glutamate receptor ionotropic, kainate 2 CHEMBL3683 | Ki | 4.32 | 4.32 | 48000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 3 | Ki | = | 6600.0 | nM | 5.18 | Binding affinity to GluK3 receptor (unknown origin) | 34998058 |
| Glutamate receptor ionotropic, kainate 1 | Ki | = | 27000.0 | nM | 4.57 | Binding affinity to GluK1 receptor (unknown origin) | 34998058 |
| Glutamate receptor ionotropic, kainate 2 | Ki | = | 48000.0 | nM | 4.32 | Binding affinity to GluK2 receptor (unknown origin) | 34998058 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34998058 | 10.1016/j.ejmech.2021.114085 | Glutamate receptor ionotropic AMPA | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | Glutamate receptor 2 | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | Glutamate receptor ionotropic, kainate 1 | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | Glutamate receptor ionotropic, kainate 2 | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | Glutamate receptor ionotropic, kainate 3 | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | Unchecked | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | Glutamate [NMDA] receptor | 1 |
Data from ChEMBL 36 via Core Engine