Assay Detail
Binding
CHEMBL5114210
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to GluK3 receptor (unknown origin)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate 3 (CHEMBL3684) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.40 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5193862 | — | — | 1 | 6.85 |
| CHEMBL5173718 | — | — | 1 | 5.96 |
| CHEMBL5209119 | — | — | 1 | 5.92 |
| CHEMBL5206048 | — | — | 1 | 5.54 |
| CHEMBL5208673 | — | — | 1 | 5.18 |
| CHEMBL5186117 | — | — | 1 | 5.05 |
| CHEMBL5198336 | — | — | 1 | 4.43 |
| CHEMBL5177751 | — | — | 1 | 4.23 |
| CHEMBL5188085 | — | — | 1 | - |
| CHEMBL5179605 | — | — | 1 | - |
| CHEMBL5187440 | — | — | 1 | - |
| CHEMBL5199355 | — | — | 1 | - |
| CHEMBL1375097 | — | — | 1 | - |
| CHEMBL5195778 | — | — | 1 | - |
| CHEMBL5174264 | — | — | 1 | - |
| CHEMBL5190991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5193862 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL5173718 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL5209119 | — | Ki | = | 1190.0 | nM | 5.92 |
| CHEMBL5206048 | — | Ki | = | 2910.0 | nM | 5.54 |
| CHEMBL5208673 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL5186117 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL5198336 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL5177751 | — | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL5188085 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL5179605 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL5187440 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL5199355 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1375097 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL5195778 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL5174264 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL5190991 | — | Ki | > | 100000.0 | nM | - |