Assay Detail
Binding
CHEMBL5114502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR del19/T790M mutant (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of the Brigatinib analogues as potent inhibitors against tertiary EGFR mutants (EGFR<sup>del19/T790M/C797S</sup> and EGFR<sup>L858R/T790M/C797S</sup>).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.58 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206715 | — | — | 1 | 10.00 |
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | 9.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206715 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3545311 | BRIGATINIB | IC50 | = | 0.7 | nM | 9.15 |