Assay Detail

CHEMBL5114532

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Functional

Cytotoxicity against human CEM cells assessed as cell growth inhibition

ChEMBL ↗

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Target

CCRF-CEM (CHEMBL382) ↗

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Primary target CCRF-CEM

CHEMBL382

Anchored from Assay target.

Protein identity CCRF-CEM

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	CCRF-CEM
Confidence	1 — Organism
Curated By	Autocuration

Target

CCRF-CEM (CHEMBL382) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Topoisomerase I inhibitors: Challenges, progress and the road ahead.

Talukdar A, Kundu B, Sarkar D, Goon S, Mondal MA.
Eur J Med Chem (2022) 236 : 114304 -114304
PubMed 35413618 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.85	7.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL373114	LAMELLARIN D	—	1	7.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL373114	LAMELLARIN D	IC50	=	14.0	nM	7.85