Assay Detail
Binding
CHEMBL5115053
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Inhibition of human carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.42 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5203184 | — | — | 1 | 7.31 |
| CHEMBL5183126 | — | — | 1 | 7.10 |
| CHEMBL5192106 | — | — | 1 | 7.09 |
| CHEMBL5201519 | — | — | 1 | 7.00 |
| CHEMBL5179294 | — | — | 1 | 6.78 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL5190695 | — | — | 1 | 6.54 |
| CHEMBL5170382 | — | — | 1 | 6.53 |
| CHEMBL5204971 | — | — | 1 | 6.48 |
| CHEMBL5203094 | — | — | 1 | 6.39 |
| CHEMBL5195261 | — | — | 1 | 6.24 |
| CHEMBL5194070 | — | — | 1 | 6.04 |
| CHEMBL5188494 | — | — | 1 | 5.77 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 5.29 |
| CHEMBL5193206 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5203184 | — | Ki | = | 49.3 | nM | 7.31 |
| CHEMBL5183126 | — | Ki | = | 79.5 | nM | 7.10 |
| CHEMBL5192106 | — | Ki | = | 81.9 | nM | 7.09 |
| CHEMBL5201519 | — | Ki | = | 98.9 | nM | 7.00 |
| CHEMBL5179294 | — | Ki | = | 165.7 | nM | 6.78 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL5190695 | — | Ki | = | 289.1 | nM | 6.54 |
| CHEMBL5170382 | — | Ki | = | 298.2 | nM | 6.53 |
| CHEMBL5204971 | — | Ki | = | 331.4 | nM | 6.48 |
| CHEMBL5203094 | — | Ki | = | 403.8 | nM | 6.39 |
| CHEMBL5195261 | — | Ki | = | 575.2 | nM | 6.24 |
| CHEMBL5194070 | — | Ki | = | 907.3 | nM | 6.04 |
| CHEMBL5188494 | — | Ki | = | 1711.0 | nM | 5.77 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 5080.0 | nM | 5.29 |
| CHEMBL5193206 | — | Ki | = | 6459.0 | nM | 5.19 |