Assay Detail
Functional
CHEMBL5115327
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Antiproliferative activity against human Adriamycin-resistant K562/Adr cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562/Adr |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of trizole-based heteroaromatic derivatives as Bcr-Abl kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.99 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5197019 | — | — | 1 | 6.00 |
| CHEMBL5207040 | — | — | 1 | 5.91 |
| CHEMBL5206449 | — | — | 1 | 5.61 |
| CHEMBL5208315 | — | — | 1 | 5.33 |
| CHEMBL5187868 | — | — | 1 | 5.02 |
| CHEMBL5187532 | — | — | 1 | 4.90 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 4.87 |
| CHEMBL5203239 | — | — | 1 | 4.60 |
| CHEMBL5207653 | — | — | 1 | 4.32 |
| CHEMBL5207090 | — | — | 1 | 4.20 |
| CHEMBL5172694 | — | — | 1 | 4.09 |
| CHEMBL5193389 | — | — | 1 | - |
| CHEMBL5183677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5197019 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5207040 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL5206449 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL5208315 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL5187868 | — | IC50 | = | 9570.0 | nM | 5.02 |
| CHEMBL5187532 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL941 | IMATINIB | IC50 | = | 13470.0 | nM | 4.87 |
| CHEMBL5203239 | — | IC50 | = | 25160.0 | nM | 4.60 |
| CHEMBL5207653 | — | IC50 | = | 48250.0 | nM | 4.32 |
| CHEMBL5207090 | — | IC50 | = | 63850.0 | nM | 4.20 |
| CHEMBL5172694 | — | IC50 | = | 80440.0 | nM | 4.09 |
| CHEMBL5193389 | — | IC50 | = | 174840.0 | nM | - |
| CHEMBL5183677 | — | IC50 | = | 187460.0 | nM | - |