Assay Detail
Functional
CHEMBL5115333
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Antiproliferative activity against mouse BaF3 cells expressing Bcr-Abl T315I mutant assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of trizole-based heteroaromatic derivatives as Bcr-Abl kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.12 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208229 | ASCIMINIB | 4.0 | 1 | 7.92 |
| CHEMBL5206449 | — | — | 1 | 6.17 |
| CHEMBL5208315 | — | — | 1 | 5.38 |
| CHEMBL5187868 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208229 | ASCIMINIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5206449 | — | IC50 | = | 672.0 | nM | 6.17 |
| CHEMBL5208315 | — | IC50 | = | 4128.0 | nM | 5.38 |
| CHEMBL5187868 | — | IC50 | = | 9466.0 | nM | 5.02 |