Assay Detail
ADMET
CHEMBL5115452
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant CYP19A1 (unknown origin) using dibenzylfluorescein as substrate incubated for 30 mins in presence of NADPH by fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of cytochrome P450 monooxygenase-catalyzed oxylipin formation by flavonoids: Evaluation of structure-activity relationship towards CYP4F2-selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.01 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16782 | 7-METHOXYFLAVONE | — | 1 | 6.29 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16782 | 7-METHOXYFLAVONE | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | IC50 | = | 1900.0 | nM | 5.72 |